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CRT0066854 hydrochloride
CAS No. 2250019-91-9
CRT0066854 hydrochloride( —— )
Catalog No. M32867 CAS No. 2250019-91-9
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 50 | Get Quote |
|
| 5MG | 73 | Get Quote |
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| 10MG | 121 | Get Quote |
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| 25MG | 198 | Get Quote |
|
| 50MG | 293 | Get Quote |
|
| 100MG | 410 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCRT0066854 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor.
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DescriptionCRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively.
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In VitroCRT0066854 hydrochloride displaces a crucial Asn-Phe-Asp motif that is part of the adenosine-binding pocket and engages an acidic patch used by arginine-rich PKC substrates.CRT0066854 hydrochloride (0.2-1.2 μM; 6 days) is able to restore polarized morphogenesis in the dysplastic H-Ras spheroids, and themaximal proportion of spheroids with PSALs is at the lower dose of 1.2 μM.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetROCK
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RecptorROCK | PKC
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Research Area——
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Indication——
Chemical Information
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CAS Number2250019-91-9
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Formula Weight488.48
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Molecular FormulaC24H27Cl2N5S
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Purity>98% (HPLC)
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Solubility——
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SMILESN[C@@H](CC1=CC=CC=C1)CNC2=C3C4=C(CCCC4)SC3=NC(C5=CC=NC=C5)=N2.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kj?r S, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J.?2013 Apr 15;451(2):329-42.?
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